Curriculum Vitae

Education Computational Biology Postdoctoral Fellow, Cancer and DNA Damage Responses
Lawrence Berkeley National Laboratory (PI: Sylvain Costes, Ph.D. and Jian-Hua Mao, Ph.D.)

Ph.D. in Bioengineering
UC Berkeley & UC San Francisco (PI: Tony Hunt, Ph.D.)

B.S. in Biomedical Engineering
Columbia University, New York, NY
Experience Exogen Biotechnology, Inc., Berkeley, CA, USA
Co-Founder, 2012 – 2016

Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Postdoctoral Fellow, Life Sciences Division, 2009 – 2015
Advisor: Sylvain Costes, Ph.D.

Brookhaven National Laboratory, Upton, NY, USA
Student, NASA Space Radiation Summer Program, 2011

University of California San Francisco, San Francisco, CA, USA
Graduate Student Researcher, Biosystems Laboratory, 2004 – 2009
Advisor: C. Anthony Hunt

University of California San Francisco, San Francisco, CA, USA
Graduate Student Instructor, Physical Chemistry, 2005

University of California Berkeley, Berkeley, CA, USA
Graduate Student Instructor, Receptor-Ligand Dynamics, 2004

Pfizer Inc., Brooklyn, NY, USA
Summer Intern, 2002

Columbia University, New York, NY, USA
Undergrad Researcher Assistant, Neurobiology Laboratory, 2000 – 2001

Columbia University, New York, NY, USA
Calculus Tutor to CU undergraduates, CU Student Tutoring Program, 1999
Honors/
Awards
Radiation Research Society Travel Award, RRS 2013, New Orleans, LA
Radiation Research Society Travel Award, RRS 2012, San Juan, Puerto Rico
NASA’s 23rd Annual Space Investigators’ Meeting Student Poster Competition, 1st Place, Durham, NC
NASA’s 22nd Annual Space Investigators’ Meeting Student Poster Competition, Honorable Mention, League City, TX
SIAM Postdoc/Early Career Travel Award, SIAM LS 2010, Pittsburgh, PA
CDH Computational and Systems Biology Fellow, UCSF
Dean’s Recognition for Excellence in Teaching Award, UCSF, Physical Chemistry
NIH Predoctoral Genomics Training Grant, UC Berkeley
Dean’s List, Columbia University (four years)
A. Peers Montgomery Memorial Scholar, Columbia University
International Baccalaureate Diploma Recipient
Peer-Reviewed Publications

Heuskin AC, Osseiran AI, Tang J, SV Costes. (2016) Simulating space radiation-induced breast tumor incidence using automata. Radiat Res. [html]
Sridharan DM, Asaithamby A, Blattnig SR, et al. (2016) Evaluating biomarkers to model cancer risk post cosmic ray exposure. Life Sci Space Res (Amst). [html]
Tang J, Huang Y, Nguyen DH, Costes SV, Snijders AM, and Mao JH. (2015) Genetic background modulates lincRNA-coordinated tissue response to low dose ionizing radiation. Int J Genomics. [html]
Georgescu W, Osseiran A, Rojec M, Yueyong L, Bombrun M, Tang J, Costes SV. (2015) Characterizing the DNA damage response by cell tracking algorithms and cell features classification using high-content time lapse analysis. PLoS One [html]
Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, and Barcellos-Hoff MH. (2014) Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53 Null Mammary Carcinomas. Cancer Res [html]
Vadhavkar N, Pham C, Georgescu W, Deschamps T, Heuskin C, Tang J, Costes SV. (2014). Combinatorial DNA damage pairing model based on X-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells. Radiation Research [html]
Barcellos-Hoff MH, Adams C, Balmain A, Costes SV, Demaria S, Illa-Bochaca I, Mao JH, Ouyang H, Sebastiano C, Tang J (2013) Systems Biology Perspectives on the Carcinogenic Potential of HZE Radiation. J Radiat Res [html]
Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruiz H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH (2014) Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. Stem Cells
[html][* In the News *]

Chiolo I, Tang J, Georgescu W, Costes SV (2013) Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin. Mutat Res – Fund Mol M.
[html] [pdf]

Dunleavy EM, Beier NL, Gorgescu W, Tang J, Costes SV, Karpen GH. (2012) The Cell Cycle Timing of Centromeric Chromatin Assembly in Drosophila Meiosis Is Distinct from Mitosis Yet Requires CAL1 and CENP-C.  PLoS Biol 10(12): e1001460. doi:10.1371/journal.pbio.1001460
[html] [pdf].

Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes SV. (2011) Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling. Integr. Biol. DOI10.1039/C0IB00092B (“5th most downloaded article of 2011” in Integrative Biology; Made the cover for the special themed issue in honor of cancer biologist, Mina Bissell)
[html] [pdf][* In the News *]

Tang J, Hunt CA. (2010) Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion. PLoS Comput Biol 6(2):e1000681. doi:10.1371/journal.pcbi.1000681
[html] [pdf]

Hunt CA, Ropella GEP, Lam TN, Tang J, Kim SHJ, Engelberg J, and Sheikh-Bahaei S (2009) At the biological modeling and simulation frontier. Pharm Res 26(11):2369-400 (DOI: 10.1007/s11095-009-9958-3).
[html]

Tang J, Hunt CA. In silico white blood cell: A synthetic model of leukocyte rolling, activation, and adhesion during inflammation. Proceedings of the ISCA 21st International Conference on Computer Applications in Industry and Engineering (CAINE 2009), November 4-6, 2009, San Francisco, CA., ISCA 2009, ISBN: 978-1-880843-73-0
Tang J, Hunt CA. In silico white blood cell: mechanisms underlying leukocyte rolling and adhesion during inflammation. Proc. of ADS 2008 SCS Spring Simulation Multiconference (SpringSim’08), The Society for Modeling and Simulation International, San Diego, CA., pp. 170-76.
Tang J, Ley KF, Hunt CA (2007) Dynamics of in silico leukocyte rolling, activation, and adhesion. BMC Syst Biol. Feb 19;1:14.
[html] [pdf]

Tang J, Hunt CA, Mellein J, Ley KF. Simulating leukocyte-venule interactions–a novel agent-oriented approach. IEEE EMBS. 2004;7:4978-81.
[html]

Abstracts Tang J, Fernandez-Garcia, Vijayakumar S, Marinez-Ruiz H, Illa-Bochaca I, Nguyen D, Mao JH, Costes SV, Barcellos-Hoff MH. Irradiation of Juvenile, but not Adult, Mammary Gland Increases Stem Cell Self-Renewal and Estrogen Receptor Negative Tumors. Presented at the Heavy Ion in Therapy and Space Radiation Symposium. Chiba, Japan. May 15 – May 18, 2013.
Demaria S, Matsumara S, Tang J, Illa-Bochaca I, Mao JH, Costes SV, Barcellos-Hoff MH. Contribution of Non-targeted Effects to HZE Carcinogenesis: Evidence for Persistent, Low Grade Inflammation. Presented at the Heavy Ion in Therapy and Space Radiation Symposium. Chiba, Japan. May 15 – May 18, 2013.
Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruiz H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH. Systems Modeling of Stem/Progenitor Self-Renewal Promotion Following Ionizing Radiation. Presented at the 58th Annual Meeting of the Radiation Research Society. San Juan, Puerto Rico, September 30 – October 3, 2012.
* Received a Travel Award

Tang J, Nguyen DH, Illa-Bochaca I, Mao JH, Costes SV, Barcellos-Hoff MH. Gene Expression Profiling of Mammary Tumors from Si-particle irradiation. Presented at the 23rd Annual NASA Space Radiation Investigators’ Workshop, Durham, NC, July 8–11, 2012.
Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruiz H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH. Systems Modeling of Stem/Progenitor Self-Renewal Promotion Following Ionizing Radiation. Presented at the 23rd Annual NASA Space Radiation Investigators’ Workshop, Durham, NC, July 8–11, 2012.
* Won Best Postdoctoral Poster Presentation Award

Tang J, Enderling H, Becker-Weimann S, Ciobanu D, Costes SV. Agent-Based Modeling of the Suppression of the Malignant Phenotype by Non-neoplastic Epithelial Cells in an In Vitro Chimeric Mammary Epithelial Acinus Model. Presented at the NCI’s Integrative Cancer Biology Program (ICBP) Mathematical Modeling Cancer Systems Meeting, Tampa, FL, March 18-20, 2012
Tang J, Chen CY, Nguyen DH, Barcellos-Hoff MH, Mao JH, Costes SV. NASA Specialized Center of Research: The Contribution of Non-Targeted Effects in HZE Cancer Risk: In Silico Model. Presented at the 22nd Annual NASA Space Radiation Investigators’ Workshop, League City, TX,September 18–21, 2011.
* Won Honorable Mention Award in the Student Poster Contest.

Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes SV. Phenotypic Transition Maps of 3D Breast Acini Obtained by Imaging-Guided Agent-Based Modeling. Presented at the 2nd Annual Physical Sciences – Oncology Centers (PS-OCs) Network Investigators’ Meeting, April 10-12, 2011, La Jolla, CA.
Tang J, Chen CY, Barcellos-Hoff MH, Costes SV. In Silico Mammary Gland: An Agent-based Systems Biology Model of Mammary Gland Carcinogenesis Following Ionizing Radiation. Presented at the 56th Annual Meeting of the Radiation Research Society, September 25-29, 2010, Maui, HI.
Tang J, Chen CY, Barcellos-Hoff MH, Costes SV. Computational Systems Modeling of the Carcinogenic Activity in Mammary Cells and Tissue byIonizing Radiation. Presented at The 4th International Systems Radiation Biology Workshop, May 20–22, 2010, New York, NY.
Tang J, Chen CY, Barcellos-Hoff MH, Costes SV. In Silico Mammary Gland: An Agent-based Systems Biology Model of Mammary Gland Carcinogenesis Following Ionizing Radiation. Presented at the 21st Annual NASA Space Radiation Investigators’ Workshop, May 16-19, 2010, Port Jefferson, NY.
Tang J, Hunt CA. A Synthetic In Silico Model of Leukocyte Rolling, Activation, and Adhesion During Inflammation. Presented at the 2009 International Conference on Complexity in Acute Illness, August 28-30, 2009, Stanford, CA, USA.
Tang J, Hunt CA. Identifying the rules of engagement enabling in silico leukocyte rolling, activation, and adhesion, Journal of Critical Care. Volume 22, Issue 4, December 2007, Page 341. Presented at the 2007 International Conference on Complexity in Acute Illness, Long beach, CA, USA, October 5-7, 2007
Tang J, Hunt CA. In silico leukocyte rolling, activation, and adhesion: Identifying the rules of engagement for leukocyte adhesion. Engineering Cell Biology II Conference Boston, MA, USA, August 5 – 8, 2007.
Tang J, Hunt CA. Synthetic modeling and simulation of leukocyte rolling on P-selectin substrate in vitro. Presented at Winter Simulation Conference. Monterey, CA, USA, December 3-6, 2006.
Tang J, Hunt CA. Simulation of leukocyte rolling, activation by GROα chemokine, and adhesion on P-selectin and VCAM-1. Presented at Computational Methods in Systems Biology Conference, The Microsoft Research Center, Trento, Italy, October 18-19, 2006.
Tang J, Hunt CA. Simulation of leukocyte interactions with a P-selectin coated substrate. Computational Systems Bioinformatics Conference, Stanford, August 14-18, 2006.
Tang J, Hunt CA, Mellein J, Ley KF. A novel agent-based approach to simulating leukocyte-venule interactions. Presented at UC Systemwide Bioengineering Symposium, Irvine, CA, June 26-28, 2004.